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Photo of Blake Anthony Wilson

PhD in ECE at Purdue, 2024

Interests
Machine learning, optimization, computer engineering, device design

Interim CEO of Zephram

Santa Barbara, CA

Academic lab

Blake Anthony Wilson

Co-Founder & Interim CEO, Zephram · Oxford, UK

I am a computer engineer often working in algorithmic optimization and machine learning, with a focus on physics-informed AI, inverse-design and hardware-software co-design. My research is deeply-interdisciplinary, involving collaborations with physicists, engineers, and mathematicians from institutions such as Oxford, Cambridge, and Harvard to develop optimized software and models for complex scientific problems, having published in venues such as Applied Physics Reviews, Nature Partner Journal, American Controls Conference, CLEO, and APS. I have led cross-functional efforts at the intersection of AI and hardware—including founding the NanoML team at Purdue and serving as PGA team lead at the Quantum Science Center while developing ML-driven quantum circuit synthesis at QuEra. My industry experience spans research roles at Purdue SoCET, QuEra, and Quantinuum, and I currently serve as interim CEO of Zephram, where I focus on full-stack multi-agent systems and inference optimization for science at large. My proprietary work while at Quantinuum includes collaborations with NVIDIA and DeepMind-aligned teams for advancing RL and transformers for quantum circuit synthesis. My work has been supported by NASA Ames, AFRL, NSF, DOE, ORNL (OLCF), and AWS Braket. To date, I have mentored 200+ researchers through programs such as SURF, SoCET alongside my personal capacity. My students have won numerous best first-time researcher awards and poster awards at conferences and internal symposiums.

Collaborators & affiliations

Cambridge University
Harvard University
Microsoft
NVIDIA
Oak Ridge National Lab
Oxford University
Purdue University
Quantum Science Center
Quantinuum
QuEra Computing
Cambridge University
Harvard University
Microsoft
NVIDIA
Oak Ridge National Lab
Oxford University
Purdue University
Quantum Science Center
Quantinuum
QuEra Computing

Announcements

  • Hiring: postdocs and visitors

    We periodically have openings for motivated researchers in ML, optimization, and scientific computing. Reach out with a CV and short research statement.

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  • Blog updates

    Notes on methods, tools, and papers appear on the lab blog.

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In the news

Recent publications

  1. Deep learning in photonic device development: nuances and opportunities

    Iyer, V., Wilson, B.A., Chen, Y., Kildishev, A.V., Shalaev, V.M., Boltasseva, A.

    npj Nanophotonics 3, 5 (2026), 2026

    Link

  2. PearSAN: A Machine Learning Method for Inverse Design Using Pearson Correlated Surrogate Annealing

    Bezick, M., Wilson, B.A., Iyer, V., Chen, Y., Shalaev, V.M., Kais, S., Kildishev, A.V., Lackey, B., Boltasseva, A.

    Advanced Optical Materials (2026): e00249, 2026

    Link

  3. Machine-learning-assisted photonic device development: a multiscale approach from theory to characterization

    Chen, Y., Montes McNeil, A., Park, T., Wilson, B., Iyer, V., Bezick, M., Choi, J., Ojha, R., Mahendran, P., Singh, D.K., Chitturi, G., Chen, P., Do, T., Kildishev, A., Shalaev, V., Moebius, M., Cai, W., Liu, Y., Boltasseva, A.

    Nanophotonics, Vol. 14, Issue 23 (July 2025), 2025

    Link

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